It is intriguing that during human cultural evolution man has detected plant natural products that appear to target key protein receptors of important physiological systems rather selectively. Plants containing such secondary metabolites usually belong to unique chemotaxa, induce potent pharmacological effects and have typically been used for recreational and medicinal purposes or as poisons. Cannabis sativa L. has a long history as a medicinal plant and was fundamental in the discovery of the
endocannabinoid system. The major psychoactive Cannabis constituent Δ9-tetrahydrocannabinol (Δ9-THC) potently activates the G-protein-coupled cannabinoid receptor CB1 and also modulates the cannabinoid receptor CB2. In the last few years, several other non-cannabinoid plant constituents have been reported to bind to and functionally interact with CB receptors. Moreover, certain plant natural products, from both Cannabis and other plants, also target other proteins of the endocannabinoid system, such as hydrolytic enzymes that control endocannabinoid levels. In this commentary we summarize and critically discuss recent findings.
This article is part of a themed issue on Cannabinoids. To view the editorial for this themed issue visit http://dx.doi.org/10.1111/j.1476-5381.2010.00831.x
Eugene Monroe made up his mind, his conviction steeled by obsessive research. He would advocate publicly for medical marijuana use in the NFL. He knew he would create consternation inside a powerful, conservative institution. He understood it might jeopardize his career as a Baltimore Ravens offensive lineman.
And the first skeptic he faced was his wife, Nureya.
When Monroe first shared his self-appointed mission in December, Nureya was confused. She had understood marijuana as illegal and dangerous since childhood, and ever since they met at the University of Virginia, she had known her husband as a health-shake-chugging, gluten-free, dairy-free, pescatarian athlete who didn’t use marijuana.
“That conversation,” Nureya said, “was a lot of me rolling my eyes.”
If you are reading this page, more than likely you or someone you know is looking for a more effective and natural way to manage a seizure disorder. The medicinal use of cannabis for its anticonvulsant properties dates back to early civilizations including ancient China, India, Africa, Greece and Rome (Chaboya-Hembree, 2014). As early as 1100 AD, Arabic writer al-Mayusi documented the use of cannabis in controlling seizures (Lozano, 2001). In our current culture, there is a vast degree of disagreement about the use of cannabis for controlling seizures. Thus far in American society, political and economic interests have been the motive for controlling and suppressing research into the medicinal uses of the Cannabis plant. Searching for information regarding the safety and efficacy of the use of Cannabis in treating seizures is no small task. In our hyper-scientific culture, ancient wisdom and natural remedies are often lost in the mix or shuffled off to the side and disregarded. This is one remedy that needs more attention, as the use of cannabis by people who struggle with seizures can be life changing.
Marijuana is also effective at reducing nausea and studies have proven that medical marijuana makes for an effective Antiemetic (antinausea) medication. For people suffering from nauseas from chemotherapy or radiation treatment, smoking marijuana relieves the nausea symptoms quickly. People are able to eat and keep the food down which helps combat weight loss and muscle wasting. The reduced nausea will reduce vomiting and reduce stress allowing for improved sleep patterns. Medical marijuana has also been shown to be effective in helping people with anorexia increase their appetite and improve their mood. Chronic nausea, a constant sensation where one feels there is a need to vomit, can be alleviated by marijuana as it reduces the nausea feeling, increases appetite, and helps keep the food down.
Medical marijuana is an effective way to treat nausea. Usually only a small amount of cannabis is needed. Most only require a few puffs of smoke or a small amount of vaporized gas from marijuana. It does not have other side effects and it will not only treat the nausea but it will probably increase their appetite as well.
Cannabis has long been used for the treatment of migraines, but only in recent years have scientists closed in on the reasons why. A new study published this week from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of Colorado looked at the effects of inhaled and ingested cannabis in migraine sufferers, and the results confirmed what previous studies had begun to unearth.
Researchers reviewed reports from 121 adult participants and collected the following data:
- The average number of migraine headaches decreased from 10.4 per month to 4.6
- Almost 40% of subjects reported positive effects
- 19.8% of subjects claimed medical marijuana helped to prevent migraines
- 11.6% of subjects reported that cannabis stopped migraine headaches
- About 85% of subjects reported having fewer migraines per month with cannabis
- About 12% saw no change in migraine frequency with cannabis
- Only about 2% experienced an increase in migraine frequency
A controlled animal study published in Daru: Journal of Faculty and Pharmacy, Tehran University of Medical Sciences found that topical treatment with 1% purified (i.e. >98%) CBD topical cream may help to reduce damage caused by a disease that results in brain inflammation. This holds relevance for humans with autoimmune diseases that lead to demyelination (damage to the fatty covering around neurons that helps them to transmit signals faster) like multiple sclerosis.
Topical CBD vs. Multiple Sclerosis Experiment
ealthy mice and mice with experimental autoimmune encephalomyelitis [(EAE)-encephalo= brain, myel= myelin= fatty nerve covering, itis= inflammation] as models for humans with multiple sclerosis, researchers applied either 1% purified CBD cream, inactive cream, or no cream to the skin of the healthy mice, and to the skin of diseased mice once symptoms of EAE began to appear. The mice were observed daily, and 28 days after EAE had been induced, spinal cord and spleen cell samples were taken.
As the black market in cannabis evolved, people figured out a way to grow their stuff one way or another. Maybe it was in a basement under lights, in a guerrilla patch in the middle of a national park, or in pots hanging from trees—because ganja seems to grow anywhere prying eyes won’t find it. But now that the fight for legalization appears to be on its way to victory, cannabis cultivators of the future—and some from the present—will have the chance to revisit the question: “Should I go indoor or outdoor?”
We’ll present all sides of this debate to allow our readers to make their own decision. Check out two radically opposing perspectives on the issue, as well as a discussion of the true carbon footprint of cannabis. Remember, the following statements don’t necessarily represent the opinion of HIGH TIMES. We smoke and dab all cannabis equally, and we don’t discriminate against or favor one cultivation method over another.
Indoor Pot Is Best! By Josh Haupt
Mother Nature gave us an amazing plant, and I will forever respect outdoor-grown cannabis. However, as with so much else, the technology for cannabis cultivation has far exceeded what was available in previous decades. It’s almost unfair to put outdoor and indoor cannabis growing in the same category: Outdoor grows rely on Mother Nature to control the most important variables, while indoor-gardening techniques will allow you to control the same factors with ease.
The fortitude demonstrated by cancer patients and survivors is truly remarkable. With numerous reviewers on Leafly using cannabis to combat the effects of various types of cancer, chemotherapy, and related medications, we’re constantly inspired by the positivity, bravery and determination that shines through their stories.
Today, on National Cancer Survivors Day, we honor these individuals. The following are just a sampling of the strains that have helped cancer patients deal with the physical, emotional, and psychological effects of their condition as they fight toward joining the ranks of hundreds of thousands of cancer survivors across the nation and around the world.
“AK-48 has helped me in so many ways with respect to my cancer. My appetite has resumed as normal, I sleep GREAT, less depression, moments of bliss, less pain and increased level of hope for survival. It is, without a doubt, my personal favorite.” –Good-juju
Fibromyalgia is a difficult condition to live with, but as we’ve learned from Leafly reviewers, cannabis can offer respite. It makes sense when you look at some of the symptoms fibro sufferers face:
- Joint pain
- Depression and anxiety
- Tenderness and generalized pain
- Inability to focus
There isn’t a lot of research on cannabis as a treatment for fibromyalgia, but clinical studies using synthesized THC for symptom management shows promising results. Still, there’s plenty of anecdotal evidence in Leafly’s strain reviews alone to show that cannabis is certainly providing much needed relief to many of those willing to experiment. These 10 strains, according to our user-submitted strain data, seem to be doing the trick.
Keep in mind, relief is not limited to these strains alone. There a lot – and we mean a lot – of strains that can treat pain, fight fatigue, reduce depression and anxiety, sharpen focus, andcrush insomnia. Consider trying other high-CBD strains, or cannabis in various other forms likeedibles, topicals, or ingestible oils. Everyone’s body is different, so the key is to try different strains and products to see what works best for you.