It is intriguing that during human cultural evolution man has detected plant natural products that appear to target key protein receptors of important physiological systems rather selectively. Plants containing such secondary metabolites usually belong to unique chemotaxa, induce potent pharmacological effects and have typically been used for recreational and medicinal purposes or as poisons. Cannabis sativa L. has a long history as a medicinal plant and was fundamental in the discovery of the
endocannabinoid system. The major psychoactive Cannabis constituent Δ9-tetrahydrocannabinol (Δ9-THC) potently activates the G-protein-coupled cannabinoid receptor CB1 and also modulates the cannabinoid receptor CB2. In the last few years, several other non-cannabinoid plant constituents have been reported to bind to and functionally interact with CB receptors. Moreover, certain plant natural products, from both Cannabis and other plants, also target other proteins of the endocannabinoid system, such as hydrolytic enzymes that control endocannabinoid levels. In this commentary we summarize and critically discuss recent findings.
This article is part of a themed issue on Cannabinoids. To view the editorial for this themed issue visit http://dx.doi.org/10.1111/j.1476-5381.2010.00831.x
Continue reading “Phytocannabinoids beyond the Cannabis plant – do they exist?”
Eugene Monroe made up his mind, his conviction steeled by obsessive research. He would advocate publicly for medical marijuana use in the NFL. He knew he would create consternation inside a powerful, conservative institution. He understood it might jeopardize his career as a Baltimore Ravens offensive lineman.
And the first skeptic he faced was his wife, Nureya.
When Monroe first shared his self-appointed mission in December, Nureya was confused. She had understood marijuana as illegal and dangerous since childhood, and ever since they met at the University of Virginia, she had known her husband as a health-shake-chugging, gluten-free, dairy-free, pescatarian athlete who didn’t use marijuana.
“That conversation,” Nureya said, “was a lot of me rolling my eyes.”
Continue reading “Ravens lineman pushing marijuana on the NFL”
As the black market in cannabis evolved, people figured out a way to grow their stuff one way or another. Maybe it was in a basement under lights, in a guerrilla patch in the middle of a national park, or in pots hanging from trees—because ganja seems to grow anywhere prying eyes won’t find it. But now that the fight for legalization appears to be on its way to victory, cannabis cultivators of the future—and some from the present—will have the chance to revisit the question: “Should I go indoor or outdoor?”
We’ll present all sides of this debate to allow our readers to make their own decision. Check out two radically opposing perspectives on the issue, as well as a discussion of the true carbon footprint of cannabis. Remember, the following statements don’t necessarily represent the opinion of HIGH TIMES. We smoke and dab all cannabis equally, and we don’t discriminate against or favor one cultivation method over another.
Indoor Pot Is Best! By Josh Haupt
Mother Nature gave us an amazing plant, and I will forever respect outdoor-grown cannabis. However, as with so much else, the technology for cannabis cultivation has far exceeded what was available in previous decades. It’s almost unfair to put outdoor and indoor cannabis growing in the same category: Outdoor grows rely on Mother Nature to control the most important variables, while indoor-gardening techniques will allow you to control the same factors with ease.
Continue reading “The Big Grow Debate: Which Is Better, Indoor or Outdoor Pot?”
Benefits of Salt Baths
There are so many health benefits to a relaxing salt bath and I definitely try to squeeze them in when I can (which usually ends up being about once a month). Salt baths are great for:
- Stress relief
- Reducing muscle aches
- Improving circulation
- Better nutrient absorption
- Headache relief
- Speeding up wound healing
- During illness, especially respiratory illness
- For children to help mineral absorption and improve sleep
- For acne, eczema or other skin problems
- For joint pain relief
- To help relieve poison ivy or skin reactions
- Improving skin hydration
- 2 cups epsom salts
- 1/2 cup baking soda
- 1/4 cup sea salt (optional)
- 30 drops of lavender essential oils
- 10 drops of peppermint essential oil
- Mix all ingredients in a medium size bowl.
- Store in an air-tight jar and use 1/4 cup per bath.
Cinnamon is a highly delicious spice. It has been prized for its medicinal properties for thousands of years. Modern science has now confirmed what people have instinctively known for ages.
Here are 10 health benefits of cinnamon that are supported by scientific research.
1. Cinnamon is High in a Substance With Powerful Medicinal Properties
Cinnamon is a spice that is made from the inner bark of trees called Cinnamomum.
It has been used as an ingredient throughout history, dating back as far as Ancient Egypt. It used to be rare and valuable, and was regarded as a gift fit for kings.
Continue reading “10 Evidence-Based Health Benefits of Cinnamon”
The fortitude demonstrated by cancer patients and survivors is truly remarkable. With numerous reviewers on Leafly using cannabis to combat the effects of various types of cancer, chemotherapy, and related medications, we’re constantly inspired by the positivity, bravery and determination that shines through their stories.
Today, on National Cancer Survivors Day, we honor these individuals. The following are just a sampling of the strains that have helped cancer patients deal with the physical, emotional, and psychological effects of their condition as they fight toward joining the ranks of hundreds of thousands of cancer survivors across the nation and around the world.
“AK-48 has helped me in so many ways with respect to my cancer. My appetite has resumed as normal, I sleep GREAT, less depression, moments of bliss, less pain and increased level of hope for survival. It is, without a doubt, my personal favorite.” –Good-juju
Continue reading “These Cancer Survivors Share Their Preferred Cannabis Strains”
Fibromyalgia is a difficult condition to live with, but as we’ve learned from Leafly reviewers, cannabis can offer respite. It makes sense when you look at some of the symptoms fibro sufferers face:
There isn’t a lot of research on cannabis as a treatment for fibromyalgia, but clinical studies using synthesized THC for symptom management shows promising results. Still, there’s plenty of anecdotal evidence in Leafly’s strain reviews alone to show that cannabis is certainly providing much needed relief to many of those willing to experiment. These 10 strains, according to our user-submitted strain data, seem to be doing the trick.
Keep in mind, relief is not limited to these strains alone. There a lot – and we mean a lot – of strains that can treat pain, fight fatigue, reduce depression and anxiety, sharpen focus, andcrush insomnia. Consider trying other high-CBD strains, or cannabis in various other forms likeedibles, topicals, or ingestible oils. Everyone’s body is different, so the key is to try different strains and products to see what works best for you.
Continue reading “Best Cannabis Strains for Fibromyalgia”